Description

cis-5-Fluoro-1-[2-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione-13C,15N2 is a stable isotope-labeled nucleoside analog derivative, specifically designed for advanced pharmaceutical research and development. This compound serves as a critical analytical standard and synthetic intermediate, enabling precise metabolic and pharmacokinetic studies. It is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing antiviral therapies and conducting high-sensitivity mass spectrometry analysis.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in bioanalytical methods for drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolic Pathway Tracing: The 13C and 15N2 labels allow for accurate tracking of drug metabolites in complex biological matrices.
• Pharmaceutical Intermediate: A key building block in the synthesis of novel, isotopically labeled nucleoside-based antiviral agents.
• Reference Material for Quality Control: Provides an absolute standard for purity and identity verification of active pharmaceutical ingredients (APIs) and related substances.
• Proteomics and Biomarker Research: Facilitates stable isotope labeling techniques in mass spectrometry-based proteomic analyses.
• Regulatory Submissions: Supports Investigational New Drug (IND) and New Drug Application (NDA) filings by providing definitive characterization data.

Basic Information

Item	Detail
Product Name	cis-5-Fluoro-1-[2-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione-13C,15N2
CAS No.	1217650-77-5
Molecular Formula	C1413CH22FN15N2O4SSi
Molecular Weight	Contact for details
Synonyms	5-Fluoro-1-[2-[[(tert-butyldimethylsilyl)oxy]methyl]-1,3-oxathiolan-5-yl]cytosine-13C,15N2; cis-FTC TBDMS ether-13C,15N2; Isotopically Labeled Emtricitabine Intermediate-13C,15N2; 2'-Deoxy-3'-thia-5-fluorocytosine TBDMS derivative-13C,15N2; [13C,15N2]-5-Fluoro-1-[(2R,5S)-2-[[(tert-butyldimethylsilyl)oxy]methyl]-1,3-oxathiolan-5-yl]cytosine; [13C,15N2]-FTC TBDMS; 13C,15N2-Labeled Nucleoside Analog
EINECS	Contact for details

Quality Control

Every batch of our isotope-labeled compounds is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR (1H, 13C, 19F), mass spectrometry (HRMS), and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and all relevant analytical data to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 98 atom % 15N
Chemical Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.