Description

(2R)-2-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-2-Methyl-3-Butynoic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a terminal alkyne functional group. This compound is a critical Fmoc-protected building block designed for advanced solid-phase peptide synthesis (SPPS), enabling the precise incorporation of structural complexity into peptide chains. It is essential for researchers and manufacturers in pharmaceutical R&D and bioconjugation, particularly for developing peptide-based therapeutics, diagnostic probes, and novel chemical entities.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of complex peptides, especially those requiring non-proteinogenic amino acids with alkyne handles.
• Click Chemistry & Bioconjugation: The terminal alkyne moiety allows for efficient, site-specific conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-functionalized molecules like dyes, polymers, or drug payloads.
• Pharmaceutical Intermediate: Serves as a crucial chiral intermediate in the research and development of novel peptide-based drugs, including oncology and metabolic disorder therapeutics.
• Peptidomimetic Design: Used to create peptide analogs and mimetics with enhanced stability, bioavailability, and target specificity by introducing constrained or modified residues.
• Chemical Biology Probes: Enables the synthesis of activity-based probes and affinity tags for studying protein function, interactions, and localization within biological systems.
• Material Science & Surface Functionalization: Facilitates the creation of peptide-functionalized surfaces, hydrogels, and nanomaterials for biosensing and tissue engineering applications.

Basic Information

Product Name	(2R)-2-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-2-Methyl-3-Butynoic Acid
CAS No.	1217628-27-7
Molecular Formula	C21H19NO5
Molecular Weight	365.38 g/mol
Synonyms	Fmoc-(R)-2-Amino-2-methyl-3-butynoic acid; Fmoc-D-2-Methyl-3-butynylglycine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylbut-3-ynoic acid; Fmoc-D-Aib(3-butynyl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-butyn-2-yl-D-glycine; Fmoc-D-2-Methyl-3-butynoic acid; Nα-Fmoc-(R)-2-amino-2-methyl-3-butynoic acid
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chiral purity and chemical integrity. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided to support your GMP-compliant research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.