Description

Mecamylamine-D3 Hydrochloride is a deuterated isotopologue of the non-depolarizing ganglionic blocker, mecamylamine hydrochloride, where three hydrogen atoms are replaced by deuterium. This labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reproducibility in analytical methods. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development for the parent drug.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the precise quantification of mecamylamine in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in stable isotope dilution assays to study the absorption, distribution, metabolism, and excretion (ADME) profile of mecamylamine.
• Bioanalytical Method Development and Validation: Enables the development of robust, validated analytical methods compliant with FDA, EMA, and ICH guidelines.
• Clinical and Pre-clinical Research: Supports therapeutic drug monitoring and toxicology studies in both clinical trials and pre-clinical animal models.
• Reference Material for Spectroscopy: Acts as a certified reference material (CRM) for nuclear magnetic resonance (NMR) spectroscopy and other isotopic analyses.

Basic Information

Product Name	Mecamylamine-D3 Hydrochloride
CAS No.	1217625-71-2
Molecular Formula	C11H18D3ClN
Molecular Weight	203.78 g/mol (for monoisotopic mass)
Synonyms	N-2,3,3-Trimethyl-2-norbornanamine-D3 hydrochloride; 3-Methylaminoisocamphane-D3 hydrochloride; Inversine-D3; Mecamylamine-d3 HCl; (1R,2S,4R)-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine-d3 hydrochloride; Deuterated Mecamylamine HCl; Mecamylamine (trimethyl-d3) hydrochloride
EINECS	Contact for details

Quality Control

Our Mecamylamine-D3 Hydrochloride is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity for critical research applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, isotopic enrichment (typically ≥98 atom % D), and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.