Description

n-Desmethyl Zolmitriptan-D3 is a stable isotope-labeled internal standard, specifically a deuterated analog of a key zolmitriptan metabolite. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and clinical trial support for migraine therapeutics.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of n-Desmethyl Zolmitriptan in biological matrices (plasma, serum, urine).
• Pharmacokinetic (PK) and Metabolism Studies: Enables accurate tracking of the absorption, distribution, metabolism, and excretion (ADME) profile of zolmitriptan in preclinical and clinical research.
• Method Development and Validation: Used as a reference compound to develop, optimize, and validate robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Doping Control and Forensic Analysis: Acts as a reference standard in specialized testing for prohibited substances in sports or forensic toxicology investigations.
• Quality Control in Manufacturing: Supports impurity profiling and stability testing of zolmitriptan active pharmaceutical ingredient (API) and finished drug products.

Basic Information

Product Name	n-Desmethyl Zolmitriptan-D3
CAS No.	1217623-11-4
Molecular Formula	C15H18D3N5O2
Molecular Weight	292.37 g/mol
Synonyms	Zolmitriptan N-Desmethyl-D3; 4-[[(3R)-3-(Dimethylamino)-2,3-dihydro-1H-indol-5-yl]methyl]-N,N-dimethyl-2,5-dihydro-1H-imidazole-1-ethanamine-2,2,2-d3; (R)-5-[[2-(Dimethylamino-d3)ethyl]-4,5-dihydro-1H-imidazol-1-yl]methyl]-1-methyl-1H-indole-3-methanol-d0; Deuterated n-Desmethyl Zolmitriptan; Zolmitriptan Metabolite M9-D3; Zolmitriptan-d3 Metabolite
EINECS	Contact for details

Quality Control

Every batch of n-Desmethyl Zolmitriptan-D3 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic purity, chemical purity (by HPLC), and identity confirmation (by NMR and MS) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity (by NMR)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.