Description

Boc-(S)-α-(2-Furanylmethyl)-Proline is a protected amino acid derivative, specifically a proline analog with a furan-containing side chain. This compound is a critical chiral building block in the synthesis of complex pharmaceutical intermediates and peptide-based therapeutics. It is essential for research and development chemists in the pharmaceutical, biotechnology, and agrochemical industries who require high-purity, structurally defined components for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor research.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce constrained, non-natural amino acid residues that modulate peptide conformation and biological activity.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Bioconjugation: Potential use in the synthesis of peptide-drug conjugates (PDCs) and other bioconjugates due to its functionalized side chain.
• Agrochemical Research: Employed in the synthesis of bioactive compounds for crop protection and pest management.
• Academic & Contract Research: Fundamental reagent for synthetic organic chemistry research and development services.

Basic Information

Product Name	Boc-(S)-α-(2-Furanylmethyl)-Proline
CAS No.	1217622-28-0
Molecular Formula	C16H23NO5
Molecular Weight	309.36 g/mol
Synonyms	(S)-1-((tert-Butoxycarbonyl)-2-((furan-2-yl)methyl)pyrrolidine-2-carboxylic acid; Boc-α-(2-Furylmethyl)-L-proline; N-Boc-α-(2-Furanylmethyl)-L-proline; tert-Butyl (2S)-2-[(furan-2-yl)methyl]-1,2-pyrrolidinedicarboxylate; (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-2-[(furan-2-yl)methyl]pyrrolidine-2-carboxylic acid; N-Boc-(S)-α-(2-Furylmethyl)proline; (S)-N-Boc-α-(2-Furylmethyl)proline
EINECS	Contact for details

Quality Control

Our Boc-(S)-α-(2-Furanylmethyl)-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from HPLC, NMR, and other relevant techniques to support cGMP and ISO standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥97.0%
Optical Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.