Description

Abt 263-D8 CAS NO 1217620-38-6 is a high-purity, deuterated compound designed for advanced research and development applications. This stable isotope-labeled analog is critical for enhancing the sensitivity and reliability of analytical methods, particularly in pharmacokinetic and metabolic studies. It serves as an essential tool for scientists and quality control professionals in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for precise quantitative analysis.
• Facilitates drug metabolism and pharmacokinetics (DMPK) studies by tracking the fate of parent drug molecules.
• Enables accurate bioanalytical method development and validation in clinical and preclinical research.
• Supports proteomics and metabolomics research where isotopic labeling is required for pathway analysis.
• Applied in environmental testing for the trace analysis of specific contaminants or their metabolites.
• Essential for forensic analysis and doping control, providing definitive identification and quantification.

Basic Information

Item	Detail
Product Name	Abt 263-D8
CAS No.	1217620-38-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Abt-263-D8; ABT263 deuterated; Navitoclax-d8; 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[4-[[(2R)-4-morpholin-2-ylphenyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide-d8; BCL-2 inhibitor-d8
EINECS	Contact for details

Quality Control

Every batch of Abt 263-D8 is manufactured under a strict quality management system. We employ advanced analytical techniques, including NMR and High-Resolution Mass Spectrometry (HRMS), to confirm structural identity and isotopic enrichment. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the label or CoA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.