Description

Ent-Calindol-13C,D2 Hydrochloride is a high-purity, isotopically labeled derivative of the calcium-sensing receptor (CaSR) antagonist, Calindol. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, ensuring superior accuracy and reliability in mass spectrometry-based analyses. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors, particularly those involved in drug metabolism and pharmacokinetics (DMPK) studies, clinical research, and the development of calcimimetic or calcilytic therapeutics.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise LC-MS/MS quantification of Calindol and its metabolites in complex biological matrices such as plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Clinical Research: Supports the development and validation of robust analytical assays for therapeutic drug monitoring and clinical trial sample analysis.
• Pharmaceutical R&D: Used in high-throughput screening and mechanistic studies targeting the calcium-sensing receptor (CaSR) pathway.
• Reference Material: Acts as a certified reference material (CRM) for method development, calibration, and ensuring regulatory compliance in analytical laboratories.

Basic Information

Product Name	Ent-Calindol-13C,D2 Hydrochloride
CAS No.	1217619-32-3
Molecular Formula	C19H19D213CN2O • HCl
Molecular Weight	Contact for details
Synonyms	Calindol-13C,D2 hydrochloride (ent-); (1R)-1-(3-Chlorophenyl)-3-[(1R)-1-(1-naphthalenyl)ethyl]-1,3-dihydro-2H-imidazol-2-one-13C,D2 hydrochloride; (R)-N-[(R)-1-(Naphthalen-1-yl)ethyl]-1-(3-chlorophenyl)imidazolidin-2-one-13C,D2 hydrochloride; NPS 2143-13C,D2 hydrochloride; CaSR antagonist-13C,D2; Isotopically labeled Calindol internal standard
EINECS	Contact for details

Quality Control

Every batch of Ent-Calindol-13C,D2 Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Certificates of Analysis (COA) are provided, detailing critical parameters such as isotopic purity, chemical purity, and absence of interfering impurities. Our quality protocols are designed to meet the stringent requirements of GMP/GLP environments and support regulatory filings (e.g., FDA, EMA).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % 13C; ≥98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.