Description

[2H6]- Zolmitriptan n-Oxide is a stable isotope-labeled analog of a key metabolite of the migraine medication Zolmitriptan. This compound is of critical importance for pharmaceutical research and development, specifically in the fields of drug metabolism and pharmacokinetics (DMPK). It serves as an essential internal standard in quantitative bioanalytical methods, enabling highly accurate and reliable measurements. Researchers and analytical laboratories in the pharmaceutical and contract research organization (CRO) sectors require this high-purity reference material to ensure data integrity in clinical and preclinical studies.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a deuterated internal standard for the precise quantification of Zolmitriptan and its metabolites in biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Facilitates the investigation of the metabolic pathways, bioavailability, and excretion profiles of Zolmitriptan.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Research: Enables accurate PK/PD modeling by providing a non-interfering standard for mass spectrometry assays.
• Bioanalytical Method Development and Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Clinical Trial Support: Used in the bioanalysis phase of clinical trials to monitor drug and metabolite levels in participants.
• Forensic and Toxicology Analysis: Supports accurate detection and quantification in forensic investigations related to drug exposure.
• Reference Standard for Quality Control: Serves as a certified reference material for calibrating instruments and verifying analytical results in quality control laboratories.

Basic Information

Product Name	[2H6]- Zolmitriptan n-Oxide
CAS No.	1217618-32-0
Molecular Formula	C16H15D6N3O3
Molecular Weight	305.38 g/mol
Synonyms	Zolmitriptan N-Oxide-d6; Deuterated Zolmitriptan N-Oxide; (S)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone N-Oxide-d6; 5-[[(4S)-4-Methyl-2-oxo-1,3-oxazolidin-3-yl]methyl]-1H-indole-3-ethanamine N-Oxide-d6; Zolmitriptan Metabolite Standard-d6; Isotopically Labeled Zolmitriptan N-Oxide; Internal Standard for Zolmitriptan Assay
EINECS	Contact for details

Quality Control

Our [2H6]- Zolmitriptan n-Oxide is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch undergoes comprehensive testing, including HPLC for chemical purity, NMR and MS for structural confirmation, and isotopic purity analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee traceability and compliance with research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.