Description

(2R,3R)-3-Amino-2-Hydroxy-3-(3-Trifluoromethyl-Phenyl)-Propionic Acid is a high-value, non-proteinogenic amino acid derivative featuring a trifluoromethylphenyl group, which imparts unique physicochemical properties critical for advanced synthesis. This compound serves as a sophisticated chiral building block and key intermediate in modern pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in the areas of protease inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Agrochemical Synthesis: Used in the creation of advanced, bioactive molecules for crop protection products, leveraging the stability of the trifluoromethyl group.
• Peptidomimetics Research: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and binding affinity due to its non-natural amino acid structure.
• Chemical Biology Probes: Serves as a building block for designing molecular probes to study enzyme function and biological pathways.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct complex chiral molecules.
• Material Science Research: Potential precursor for specialty polymers or coatings where fluorine-containing groups are desired for specific surface properties.

Basic Information

Product Name	(2R,3R)-3-Amino-2-Hydroxy-3-(3-Trifluoromethyl-Phenyl)-Propionic Acid
CAS No.	1217618-05-7
Molecular Formula	C10H10F3NO3
Molecular Weight	249.19 g/mol
Synonyms	(2R,3R)-3-Amino-2-hydroxy-3-[3-(trifluoromethyl)phenyl]propanoic acid; (R,R)-3-Amino-2-hydroxy-3-(3-trifluoromethylphenyl)propionic acid; 3-Amino-2-hydroxy-3-(3-trifluoromethylphenyl)propanoic acid (2R,3R)-isomer; β-Amino-β-(3-trifluoromethylphenyl)-D-serine; (2R,3R)-AHTPA; D-3-Amino-2-hydroxy-3-(3-trifluoromethylphenyl)propionic acid
EINECS	Contact for details

Quality Control

Our (2R,3R)-3-Amino-2-Hydroxy-3-(3-Trifluoromethyl-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.