Description

Entereg-D5 is a deuterated analog of alvimopan, a peripherally acting mu-opioid receptor antagonist. This compound is specifically designed for use as an internal standard in analytical chemistry, providing enhanced precision and reliability for quantitative analysis. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors who require accurate measurement of alvimopan in complex matrices. The product is supplied under strict quality control to ensure consistency and performance.

Application

• Pharmaceutical Research & Development: Serves as a critical internal standard in method development and validation for the quantification of alvimopan in biological samples and pharmaceutical formulations.
• Bioanalytical Assays: Used in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and High-Performance Liquid Chromatography (HPLC) to ensure accurate pharmacokinetic and pharmacodynamic studies.
• Metabolite Studies: Facilitates the identification and quantification of drug metabolites in preclinical and clinical research.
• Quality Control & Assurance: Enables precise impurity profiling and assay verification of alvimopan active pharmaceutical ingredients (APIs) and finished drug products.
• Regulatory Compliance Testing: Supports analytical testing required for regulatory submissions to agencies like the FDA and EMA.
• Stability Indicating Methods: Employed in stability studies to monitor the degradation of alvimopan under various environmental conditions.

Basic Information

Product Name	Entereg-D5
CAS No.	1217616-62-0
Molecular Formula	C25H27D5N2O4
Molecular Weight	425.56 g/mol
Synonyms	Alvimopan-d5; [[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic Acid-d5; (R)-N-((3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-2-((S)-2-methyl-3-(phenyl-d5)propanamido)acetamide; ADL 8-2698-d5; LY246736-d5
EINECS	Contact for details

Quality Control

Every batch of Entereg-D5 is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support its use as a certified reference material. Specifications typically include confirmation of chemical identity, isotopic purity (deuteration degree), and chromatographic purity by HPLC. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting batch-specific results for assay, impurities, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.