Description

Phenylpropanolamine-D5 is a deuterated internal standard of the sympathomimetic amine, phenylpropanolamine, where five hydrogen atoms are replaced with deuterium. This compound is critically important for ensuring accuracy and reliability in quantitative analytical methods, particularly in regulated environments. It is primarily needed by analytical laboratories and pharmaceutical R&D teams in the life sciences, forensic toxicology, and doping control sectors for precise mass spectrometry-based analysis.

Application

• Internal Standard for LC-MS/MS and GC-MS: Used as a quantitative reference standard in bioanalytical method development and validation for pharmacokinetic studies.
• Pharmaceutical Impurity Profiling: Employed in the identification and quantification of metabolites or degradation products in drug substance and product analysis.
• Forensic and Clinical Toxicology: Essential for the accurate measurement of phenylpropanolamine and related compounds in biological matrices like urine, blood, or plasma.
• Doping Control Analysis: Supports anti-doping laboratories in detecting and confirming the presence of banned stimulants in athlete samples.
• Stable Isotope Labeling Studies: Serves as a tracer in metabolic pathway research and mechanistic studies within pharmaceutical development.
• Quality Control in Reference Material Production: Used to certify and calibrate analytical methods for the production of certified reference materials (CRMs).

Basic Information

Product Name	Phenylpropanolamine-D5
CAS No.	1217613-87-0
Molecular Formula	C9H8D5NO
Molecular Weight	155.23 g/mol
Synonyms	PPA-D5; (±)-Norephedrine-d5; (RS)-2-Amino-1-phenyl-1-propanol-d5; dl-Norephedrine-d5; 1-Phenyl-2-amino-1-propanol-d5; α-(1-Aminoethyl)benzyl alcohol-d5; Norphedrine-d5; Racemic Norephedrine-d5
EINECS	Contact for details

Quality Control

Our Phenylpropanolamine-D5 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic purity, and residual solvents. We adhere to relevant industry standards for reference materials to ensure reliable and reproducible performance in your critical assays.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.