Description

Fmoc-D-4-Carbamoylphe CAS NO 1217610-39-3 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled introduction of the D-isomer of 4-carbamoylphenylalanine into peptide chains, enabling the creation of complex, non-natural peptides with enhanced stability and targeted biological activity. It is an essential building block for pharmaceutical R&D, particularly in the development of novel therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Research: For the development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted cancer therapies.
• Bioconjugation & Probe Development: Incorporation of a carbamoyl group for further chemical modification or as a handle for attaching fluorescent labels or affinity tags.
• Structure-Activity Relationship (SAR) Studies: Used to investigate the impact of D-amino acids and aromatic side-chain modifications on peptide bioactivity and metabolic stability.
• Academic & Industrial Biochemistry: Synthesis of substrates for enzyme studies, receptor ligands, and other specialized biochemical tools.

Basic Information

Product Name	Fmoc-D-4-Carbamoylphe
CAS No.	1217610-39-3
Molecular Formula	C25H22N2O5
Molecular Weight	430.46 g/mol
Synonyms	Fmoc-D-4-Carbamoylphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-carbamoyl-D-phenylalanine; Fmoc-D-Cpa(4-CONH2)-OH; Fmoc-D-Phe(4-CONH2)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-carbamoylphenyl)propanoic acid; N-α-Fmoc-D-4-carbamoylphenylalanine; Fmoc-D-4-(aminocarbonyl)phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-D-4-Carbamoylphe is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.