Description

4-Hydroxy Duloxetine-D6 is a deuterated analog of a key metabolite of the pharmaceutical compound duloxetine. This high-purity reference standard is essential for precise analytical quantification and metabolic pathway studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities for method development, validation, and quality control in bioanalytical assays.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, isotopically labeled internal standard for the accurate quantification of duloxetine and its metabolites in complex biological matrices like plasma and serum.
• Pharmacokinetic and Metabolism Studies: Enables detailed investigation of the absorption, distribution, metabolism, and excretion (ADME) profile of duloxetine in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to develop and validate robust, sensitive, and specific high-performance liquid chromatography (HPLC) or ultra-performance liquid chromatography (UPLC) methods coupled with mass spectrometry.
• Doping Control & Forensic Analysis: Supports the detection and confirmation of duloxetine use in sports anti-doping programs and forensic toxicology investigations.
• Pharmaceutical Impurity Profiling: Aids in the identification and characterization of related substances and degradation products during drug substance and drug product stability testing.
• Clinical Trial Support: Provides reliable data for therapeutic drug monitoring and exposure-response relationship studies during clinical trials.

Basic Information

Product Name	4-Hydroxy Duloxetine-D6
CAS No.	1217606-96-6
Molecular Formula	C18H13D6NO2
Molecular Weight	~299.4 g/mol
Synonyms	(+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine-D6 Hydrochloride; (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine-D6; Duloxetine Metabolite D6; LY248686-D6; Cymbalta Metabolite-D6
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxy Duloxetine-D6 is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and isotopic enrichment testing using advanced techniques including HPLC, NMR, and mass spectrometry to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, chemical purity, isotopic purity (D-enrichment), and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the product label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.