Description

Demecolcine-D6 is a deuterated analog of the natural alkaloid demecolcine, serving as a high-purity internal standard for precise quantitative analysis. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in sensitive analytical methods, particularly in regulated environments. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and quality control.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in Liquid Chromatography-Tandem Mass Spectrometry for bioanalytical studies of demecolcine.
• Pharmacokinetic and Metabolite Research: Enables accurate tracking and quantification of demecolcine and its metabolites in biological matrices.
• Method Development and Validation: Essential for developing and validating robust, GLP-compliant analytical methods in pharmaceutical R&D.
• Quality Control and Assurance: Supports impurity profiling and assay verification of demecolcine in active pharmaceutical ingredient (API) batches.
• Stable Isotope Dilution Analysis (SIDA): Provides the foundation for this highly accurate quantitative technique in complex sample analysis.

Basic Information

Product Name	Demecolcine-D6
CAS No.	1217602-04-4
Molecular Formula	C21H19D6NO5
Molecular Weight	377.45 g/mol
Synonyms	Demecolcine-d6; Colcemid-d6; N-Deacetyl-N-methylcolchicine-d6; Deacetylcolchicine methyl ether-d6; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-N-methylethanamide-d6; Colchamine-d6; O-Methylcolchicine-d6; Stable Isotope-Labeled Demecolcine
EINECS	Contact for details

Quality Control

Our Demecolcine-D6 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (≥98% D), chemical purity (by HPLC), and residual solvent content. We adhere to relevant industry standards for stable isotope-labeled compounds, and custom specifications for GMP or other regulatory frameworks can be discussed.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.