Description

Fmoc-L-β-Homohydroxyproline(Otbu) CAS NO 1217544-43-8 is a high-purity, protected amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over stereochemistry and side-chain functionality in complex peptide sequences. It is an essential building block for pharmaceutical R&D, particularly in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, sequential construction of custom peptides.
• Pharmaceutical Research & Development: For creating libraries of peptide-based drug candidates targeting various diseases.
• Peptidomimetic Design: Used to introduce conformational constraints and modify peptide backbones to enhance stability and bioavailability.
• Bioconjugation & Labeling: Serves as a specialized component for attaching peptides to other molecules, surfaces, or probes.
• Academic & Institutional Research: A fundamental reagent in biochemistry and medicinal chemistry laboratories studying protein structure-function relationships.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for client projects requiring high-fidelity peptide assembly.

Basic Information

Product Name	Fmoc-L-β-Homohydroxyproline(Otbu)
CAS No.	1217544-43-8
Molecular Formula	C25H29NO6
Molecular Weight	439.50 g/mol
Synonyms	Fmoc-β-HomoHyp(OtBu); Fmoc-L-β-homohydroxyproline(O-tert-butyl); (2S,4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methylpropan-2-yl)oxy]pyrrolidine-2-carboxylic acid; Fmoc-(4R)-hydroxy-L-homoproline(OtBu); N-α-Fmoc-L-β-homohydroxyproline tert-butyl ether; Fmoc-L-β-Hyp(OtBu); N-Fmoc-4(R)-tert-butoxy-L-homoproline; Protected β-Homohydroxyproline derivative
EINECS	Contact for details

Quality Control

Every batch of Fmoc-L-β-Homohydroproline(Otbu) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the stringent purity standards required for peptide synthesis. Our quality commitment includes comprehensive analysis via HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, chiral integrity, and specific impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.