Description

3-Hydroxymethyl Maraviroc-D6 is a high-purity, deuterium-labeled derivative of the active pharmaceutical ingredient Maraviroc. This compound is specifically designed for use as a critical internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolism studies. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on antiviral drug development and regulatory compliance.

Application

• Bioanalytical Internal Standard: Primary use as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS methods for the quantification of Maraviroc in biological matrices (plasma, serum, tissue).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical studies.
• Pharmaceutical Impurity Profiling: Used as a reference standard for identifying and quantifying process-related impurities and degradants in Maraviroc API batches.
• Clinical Research Support: Critical for ensuring data integrity in bioequivalence and therapeutic drug monitoring studies related to CCR5 antagonist therapies.
• Method Development and Validation: Serves as a key reagent for developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.

Basic Information

Product Name	3-Hydroxymethyl Maraviroc-D6
CAS No.	1217536-16-7
Molecular Formula	C₂₉H₃₅D₆F₂N₅O
Molecular Weight	515.68 g/mol
Synonyms	4,4-Difluoro-N-{(1S)-3-[exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide-3-hydroxymethyl-d6; Maraviroc-3-hydroxymethyl-d6; Maraviroc Metabolite Standard-d6; 8-[3-[(1S)-1-(3-Hydroxymethyl-d6-phenyl)-3-(4,4-difluorocyclohexyl)propyl]-8-azabicyclo[3.2.1]oct-3-yl]-3-isopropyl-5-methyl-1,2,4-triazole; Deuterated 3-Hydroxymethyl Maraviroc; Celsentri-d6 derivative; UK-427857-d6 metabolite
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxymethyl Maraviroc-D6 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use in GLP/GMP-regulated environments. Certificates of Analysis (COA) are supplied with each shipment, detailing purity, isotopic enrichment, and confirming the absence of unlabeled analyte. Our quality commitment ensures compliance with the stringent requirements for reference standards in pharmaceutical analysis.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.