Description

Fmoc-(2S,3Rs)-2-Amino-3-Hydroxy-4-Methylpentanoic Acid is a high-purity, non-natural amino acid derivative featuring a stereochemically defined hydroxy group and an Fmoc-protected amine. This compound is a critical building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of structural diversity and specific functional groups. It is essential for researchers and manufacturers in pharmaceutical R&D, particularly in the development of novel therapeutics, diagnostic agents, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of custom peptides with specific stereochemistry.
• Pharmaceutical Intermediates: Serves as a crucial chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetic Design: Used to create peptide analogs with enhanced metabolic stability, bioavailability, and receptor selectivity.
• Bioconjugation: The reactive carboxyl and protected amine groups allow for site-specific modification of biomolecules.
• Chemical Biology Probes: Incorporated into peptides used as tools for studying enzyme mechanisms, protein-protein interactions, and cellular pathways.
• Academic & Industrial Research: A valuable reagent for exploring new synthetic methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-(2S,3Rs)-2-Amino-3-Hydroxy-4-Methylpentanoic Acid
CAS No.	1217516-81-8
Molecular Formula	C₂₂H₂₅NO₅
Molecular Weight	383.44 g/mol
Synonyms	Fmoc-Thr(Me)-OH; Fmoc-O-methylthreonine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-threonine; (2S,3R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-hydroxy-4-methylpentanoic acid; Fmoc-(2S,3R)-2-Amino-3-hydroxy-4-methylpentanoic acid; Fmoc-L-O-methylthreonine; Fmoc-MeThr-OH; Fmoc-3-Hydroxy-4-methyl-L-norvaline
EINECS	Contact for details

Quality Control

Our Fmoc-(2S,3Rs)-2-Amino-3-Hydroxy-4-Methylpentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and correct stereochemical integrity, which are critical for sensitive peptide synthesis applications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.