Description

Itraconazole-D5 CAS NO 1217510-38-7 is a deuterated analog of the broad-spectrum antifungal agent itraconazole, where five hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of itraconazole in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical research and development, clinical laboratories, and forensic toxicology units requiring high-fidelity analytical results.

Application

• Internal Standard for Bioanalysis: Primary use as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of itraconazole in pharmacokinetic and toxicokinetic studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise measurement of drug concentration in plasma, serum, and tissues to study absorption, distribution, metabolism, and excretion (ADME) profiles.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust assays for monitoring itraconazole levels in patients to optimize dosing and ensure therapeutic efficacy.
• Forensic and Anti-Doping Analysis: Used in confirmatory testing protocols to ensure accurate identification and quantification of itraconazole in forensic and sports doping control laboratories.
• Pharmaceutical Quality Control: Can be employed in method development for impurity profiling and stability testing of itraconazole-based drug products.
• Reference Material for Metabolite Studies: Aids in the identification and quantification of itraconazole metabolites in research settings.

Basic Information

Product Name	Itraconazole-D5
CAS No.	1217510-38-7
Molecular Formula	C35H33D5Cl2N8O4
Molecular Weight	706.66 g/mol (approximate)
Synonyms	Itraconazole-d5; 4-[4-[4-[4-[[(2R*,4S*)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one-d5; Deuterated Itraconazole; Itraconazole (phenyl-d5); Itraconazole Internal Standard; R 51211-d5; Sporanox-d5
EINECS	Contact for details

Quality Control

Our Itraconazole-D5 is manufactured under controlled conditions to ensure the highest isotopic purity and chemical integrity. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to confirm deuterium incorporation, chemical purity, and absence of unlabeled compound. Certificates of Analysis (COA) detailing isotopic purity (typically ≥98% deuterium atoms), chemical purity (by HPLC), and specific analytical data are provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.