Description

4-Benzyloxy-2-Trifluoromethylphenylboronic Acid is a high-purity organoboron reagent featuring a benzyl-protected phenol and a trifluoromethyl group, making it a versatile building block for advanced synthesis. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who are developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylated biaryl motifs which enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a monomer or building block for creating advanced organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the synthesis of novel bidentate or monodentate ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	4-Benzyloxy-2-Trifluoromethylphenylboronic Acid
CAS No.	1217501-32-0
Molecular Formula	C14H12BF3O3
Molecular Weight	296.05 g/mol
Synonyms	2-(Trifluoromethyl)-4-(phenylmethoxy)benzeneboronic Acid; [4-(Benzyloxy)-2-(trifluoromethyl)phenyl]boronic Acid; 4-(Benzyloxy)-2-(trifluoromethyl)benzeneboronic Acid; B-[4-(Benzyloxy)-2-(trifluoromethyl)phenyl]boronic Acid; 4-Benzyloxy-2-trifluoromethylbenzeneboronic Acid; 4-(Benzyloxy)-α,α,α-trifluoro-o-tolylboronic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Benzyloxy-2-Trifluoromethylphenylboronic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR (¹H, ¹³C, ¹¹B), and mass spectrometry. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.