Description

4-Fluoro-3-(Thpo)Phenylboronic Acid is a high-value, synthetically versatile organoboron reagent featuring a tetrahydropyranyl (THP) protected hydroxyl group. This compound is specifically engineered for advanced cross-coupling reactions, such as the Suzuki-Miyaura coupling, where its protected functionality prevents unwanted side reactions and enables sequential synthetic strategies. It is an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating complex, multi-functional aromatic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atom and protected phenol enhance bioactivity and environmental stability.
• Material Science Research: Serves as a monomer or building block for developing novel organic electronic materials, liquid crystals, and polymers with specific optical or electronic properties.
• Suzuki-Miyaura Cross-Coupling: The primary application is in palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures, fundamental in medicinal chemistry.
• Protecting Group Chemistry: The THP-protected phenol allows for selective reactions on the boronic acid moiety, with subsequent deprotection to reveal the phenolic OH for further functionalization.
• Ligand Synthesis: Useful for constructing sophisticated chelating ligands for catalysis used in asymmetric synthesis and industrial chemical processes.

Basic Information

Product Name	4-Fluoro-3-(Thpo)Phenylboronic Acid
CAS No.	1217501-17-1
Molecular Formula	C11H14BFO3
Molecular Weight	224.04 g/mol
Synonyms	4-Fluoro-3-((tetrahydro-2H-pyran-2-yl)oxy)benzeneboronic acid; (4-Fluoro-3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)boronic acid; 3-(THPO)-4-Fluorophenylboronic Acid; 4-Fluoro-3-(tetrahydropyran-2-yloxy)phenylboronic acid; B-[4-Fluoro-3-(tetrahydro-2H-pyran-2-yloxy)phenyl]boronic acid; CAS 1217501-17-1
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-(Thpo)Phenylboronic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality protocol includes identity confirmation by NMR and FT-IR, purity assessment by HPLC, and control of key impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. Specifications can be tailored to meet the requirements of cGMP, ICH Q7, or other relevant regulatory frameworks for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container for use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.