Description

Cbz-D-Trp(Boc)-Oh is a protected amino acid derivative, specifically a tryptophan analog, widely used as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptides with specific chiral configurations. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for the development of therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-tryptophan into peptide chains, enabling the creation of peptides with enhanced metabolic stability and biological activity.
• Pharmaceutical Research & Development: Serves as a crucial raw material in the R&D of novel peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation and Labeling: Used in the preparation of peptide conjugates for diagnostic imaging, drug delivery systems, and affinity chromatography ligands.
• Academic & Biochemical Studies: Employed in university and institutional labs to study peptide structure-activity relationships (SAR) and to synthesize custom peptides for biological assays.
• Process Development & Scale-up: Supports process chemistry teams in developing scalable and efficient synthetic routes for peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Cbz-D-Trp(Boc)-Oh
CAS No.	1217471-55-0
Molecular Formula	C26H30N2O6
Molecular Weight	466.53 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-D-tryptophan N-tert-butyloxycarbonyl; N-Cbz-D-tryptophan N-Boc; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid (Related Fmoc variant); Z-D-Trp(Boc)-OH; Carbobenzoxy-D-tryptophan tert-butyl ester; Nα-Cbz-Nin-Boc-D-tryptophan; D-Tryptophan, N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester; Boc-D-Trp(Boc)-OH (Common misnomer)
EINECS	Contact for details

Quality Control

Our Cbz-D-Trp(Boc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards, and custom purity grades (e.g., >98%, >99%) are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.