Description

Fmoc-(S)-3-Amino-(6-Phenyl)-5-Hexenoicacid CAS NO 1217460-65-5 is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a terminal phenyl-substituted alkene side chain. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the introduction of unique structural motifs. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and CROs engaged in the development of novel therapeutic peptides, protein engineering, and chemical biology research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral intermediate for the automated synthesis of custom peptides with specific structural features.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drug candidates, including enzyme inhibitors and receptor modulators.
• Peptidomimetic Design: Incorporates a rigid, hydrophobic phenyl-alkene side chain to mimic protein secondary structures and enhance metabolic stability.
• Chemical Biology Probes: Serves as a building block for creating labeled or modified peptides used in biochemical assays and target identification.
• Academic Research: Employed in university and institutional labs for studying peptide structure-activity relationships (SAR) and molecular recognition.
• Bioconjugation: The reactive alkene handle can be used for further functionalization via click chemistry or other coupling reactions.

Basic Information

Product Name	Fmoc-(S)-3-Amino-(6-Phenyl)-5-Hexenoicacid
CAS No.	1217460-65-5
Molecular Formula	C27H25NO4
Molecular Weight	427.49 g/mol
Synonyms	Fmoc-(S)-3-Amino-6-phenyl-5-hexenoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-6-phenyl-5-hexenoic acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-phenylhex-5-enoic acid; Fmoc-Ahph(6-Phe)-OH; Fmoc-3-Amino-6-phenyl-5-hexenoic acid; Fmoc-(S)-3-Ahph(6-Phe)-OH; Fmoc-DL-3-Amino-6-phenyl-5-hexenoic acid (racemic mixture reference)
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-(6-Phenyl)-5-Hexenoicacid is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot is subjected to rigorous analytical testing, including chiral purity verification by HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.