Description

3, 3'-Diiodo-L-Thyronine-(Phenoxy-13C6) (T2) is a stable isotope-labeled analog of the thyroid hormone metabolite 3,3'-Diiodothyronine. This compound is a critical tool for precise quantitative analysis in biomedical research, offering unmatched accuracy in mass spectrometry-based assays. It is primarily utilized by pharmaceutical R&D teams, clinical research organizations, and analytical laboratories focused on endocrinology, metabolism, and thyroid hormone pathway studies.

Application

• Internal Standard for LC-MS/MS: Serves as a high-purity, isotopically labeled internal standard for the accurate quantification of endogenous T2 and related thyroid hormones in complex biological matrices like serum, plasma, and tissue homogenates.
• Metabolic Pathway Research: Enables detailed investigation of thyroid hormone metabolism, deiodination pathways, and the biological activity of T2 metabolites in in vitro and in vivo studies.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Essential for tracing the absorption, distribution, metabolism, and excretion (ADME) of thyroid hormone analogs in drug discovery programs.
• Clinical Assay Development & Validation: Used as a reference material in the development and calibration of robust diagnostic assays for thyroid function testing.
• Biomarker Discovery: Facilitates the identification and validation of thyroid hormone-related biomarkers in metabolic disorders, cardiovascular disease, and cancer research.

Basic Information

Product Name	3, 3'-Diiodo-L-Thyronine-(Phenoxy-13C6) (T2)
CAS No.	1217459-13-6
Molecular Formula	C15H1313C6I2NO4
Molecular Weight	~655.08 g/mol
Synonyms	3,3'-T2-(Phenoxy-13C6); L-3,3'-Diiodothyronine-(Phenoxy-13C6); [Phenoxy-13C6]-3,3'-Diiodo-L-thyronine; 3,3'-Diiodothyronine-13C6; Isotopically Labeled T2; 13C6-T2; T2 Internal Standard; (2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic-13C6 acid
EINECS	Contact for details

Quality Control

Every batch of 3, 3'-Diiodo-L-Thyronine-(Phenoxy-13C6) (T2) is manufactured and analyzed under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed data for HPLC purity, isotopic enrichment, and structural confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 99 atom % 13C
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.