Description

Topiramate-13C6 is a stable isotope-labeled analog of the anticonvulsant drug Topiramate, where six carbon atoms are replaced with the Carbon-13 isotope. This compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical material for pharmaceutical research and development, clinical laboratories, and forensic toxicology studies focused on drug metabolism and pharmacokinetics.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for bioanalytical method development and validation.
• Drug Metabolism Studies (DMPK): Used in Absorption, Distribution, Metabolism, and Excretion (ADME) research to track and quantify Topiramate and its metabolites in biological matrices.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Enables precise measurement of Topiramate concentrations in patient plasma or serum to optimize dosing regimens.
• Forensic and Toxicology Analysis: Supports accurate identification and quantification of Topiramate in forensic investigations and toxicological screenings.
• Pharmaceutical Quality Control: Can be utilized in impurity profiling and assay development for Topiramate drug substance and finished product testing.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the labeled spike in IDMS, the gold-standard technique for achieving definitive measurement accuracy.

Basic Information

Product Name	Topiramate-13C6
CAS No.	1217455-55-4
Molecular Formula	C136H21NO8S
Molecular Weight	351.36 g/mol (labeled)
Synonyms	Topiramate (13C6); 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate-13C6; Topamax-13C6; 13C6-Topiramate; Isotopically Labeled Topiramate; [13C6]-Topiramate; 1H-1,2,4-Triazole-3-carboxamide, 5-amino-1-β-D-ribofuranosyl-13C6; (IS,3S,5R,6R,8S,10S,11R,12S,15R)-3,4,5,6,7,8,10,11,12,13,15,16,17,18-Tetradecahydro-3,10:12,15-dimetheno-6H,14H-5,8-methanofuro[3,2-l][3,7,12]trioxacyclopentadecino[2,3-d]pyrazole-6,14-dione-13C6
EINECS	Contact for details

Quality Control

Every batch of Topiramate-13C6 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% chemical purity, ≥99% isotopic enrichment), and suitability for use as an internal standard. Our quality commitment ensures compliance with the rigorous standards required for analytical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.