Description

(E/Z)-4,4’-Dihydroxy-n-Desmethyl Tamoxifen CAS NO 1217247-19-2 is a high-purity, advanced pharmaceutical intermediate and reference standard. This compound is a key metabolite and synthetic precursor in the development and analysis of selective estrogen receptor modulators (SERMs). It is essential for researchers and manufacturers in the pharmaceutical industry requiring precise chemical tools for drug development, metabolite studies, and quality control processes.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments and validation of testing methods in drug quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical building block in the synthesis of novel SERM compounds and related therapeutic agents.
• Metabolite Research: Employed in pharmacokinetic and pharmacodynamic studies to understand the metabolic pathways and biological activity of tamoxifen analogs.
• Biochemical Research: Utilized as a tool compound in vitro to study estrogen receptor interactions and mechanisms of action.
• Analytical Chemistry: Acts as a high-purity standard for HPLC, LC-MS, and other chromatographic analyses in contract research organizations (CROs).

Basic Information

Product Name	(E/Z)-4,4’-Dihydroxy-n-Desmethyl Tamoxifen
CAS No.	1217247-19-2
Molecular Formula	C25H27NO2
Molecular Weight	373.49 g/mol
Synonyms	4,4'-Dihydroxydesmethyltamoxifen; 4,4'-Dihydroxydesmethyltamoxifen (E/Z mixture); 1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-buten-3-ol; 4-Hydroxy-N-desmethyltamoxifen; 4'-Hydroxy-N-desmethyltamoxifen; Endoxifen Impurity; Z-Endoxifen Impurity
EINECS	Contact for details

Quality Control

Our (E/Z)-4,4’-Dihydroxy-n-Desmethyl Tamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0% (Area %)
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.