Description

(E/Z)-N,n-Didesmethyl-4-Hydroxy Tamoxifen is a key active metabolite and reference standard of the widely used breast cancer therapeutic, Tamoxifen. This compound matters for its critical role in pharmacological research, metabolism studies, and the development of analytical methods for therapeutic drug monitoring. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on oncology, endocrinology, and analytical chemistry.

Application

• Pharmacological Reference Standard: Used as a high-purity standard for the quantification of Tamoxifen and its metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Metabolism and Pharmacokinetics (PK/PD) Studies: Essential for investigating the metabolic pathways, bioavailability, and efficacy of Tamoxifen in preclinical and clinical research.
• Biomarker Research: Employed in studies to understand individual patient response to Tamoxifen therapy and its correlation with metabolite levels.
• Analytical Method Development and Validation: Serves as a critical component for developing, calibrating, and validating sensitive and specific assays in quality control laboratories.
• Impurity Profiling: Used to identify and quantify related substances in Tamoxifen active pharmaceutical ingredient (API) and finished drug products.
• Biochemical Research: Applied in in vitro studies to investigate the mechanism of action of selective estrogen receptor modulators (SERMs) at the molecular level.

Basic Information

Product Name	(E/Z)-N,n-Didesmethyl-4-Hydroxy Tamoxifen
CAS No.	1217237-98-3
Molecular Formula	C24H27NO2
Molecular Weight	361.48 g/mol
Synonyms	4-Hydroxydesmethyltamoxifen; N-Desmethyl-4-hydroxytamoxifen; Endoxifen Impurity; (Z)-4-Hydroxy-N-desmethyltamoxifen; (E)-4-Hydroxy-N-desmethyltamoxifen; Tamoxifen Metabolite Y; Tamoxifen Metabolite Z; FC-1271a
EINECS	Contact for details

Quality Control

Our (E/Z)-N,n-Didesmethyl-4-Hydroxy Tamoxifen is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and reference material applications. A comprehensive Certificate of Analysis (COA) detailing purity, isomer ratio, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0% (Total of E and Z isomers)
Isomer Ratio (E/Z)	Specified on COA
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.