Description

Zafirlukast-D7 is a deuterated internal standard of the leukotriene receptor antagonist Zafirlukast, specifically labeled with seven deuterium atoms. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analysis in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical research and development, quality control laboratories, and clinical diagnostic facilities requiring precise bioanalytical measurements.

Application

• Internal standard for the quantitative analysis of Zafirlukast in biological matrices (e.g., plasma, serum) using Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Metabolite identification and profiling studies in drug metabolism and pharmacokinetics (DMPK) research.
• Use in bioequivalence and bioavailability studies for generic drug development.
• Calibration and validation of analytical methods in pharmaceutical quality control laboratories.
• Supporting clinical trial analysis for therapeutic drug monitoring.
• Research into the pharmacokinetic properties and clearance pathways of leukotriene receptor antagonists.

Basic Information

Product Name	Zafirlukast-D7
CAS No.	1217174-18-9
Molecular Formula	C31H26D7N3O6S
Molecular Weight	~ 584.7 g/mol
Synonyms	Zafirlukast-d7; [D7]-Zafirlukast; 4-(5-Cyclopentyloxy-2-hydroxy-4-(1-methyld3-1H-tetrazol-5-yl)butoxy-d4phenyl)-3-methoxy-N-(o-tolylsulfonyl)benzamide; Accolate-d7 (deuterated); ICI-204,219-d7; Isotopically Labeled Zafirlukast
EINECS	Contact for details

Quality Control

Our Zafirlukast-D7 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D7), chemical purity (by HPLC), and identity confirmation. We adhere to cGMP guidelines for the production of reference standards, ensuring traceability, consistency, and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D7)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.