Description

n-Acetyl Sulfadiazine-13C6 is a stable isotope-labeled analog of the sulfonamide antibiotic intermediate, where six carbon atoms are replaced with the 13C isotope. This compound is essential as an internal standard in quantitative mass spectrometry, providing unmatched accuracy and reliability for pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in advanced drug development and regulatory bioanalysis.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS methods for the precise quantification of sulfadiazine and its metabolites in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracing of drug absorption, distribution, metabolism, and excretion (ADME) pathways in preclinical and clinical studies.
• Veterinary Pharmaceutical Research: Used in studies monitoring sulfadiazine residues in food-producing animals to ensure compliance with maximum residue limits (MRLs).
• Clinical Trial Support: Provides method validation and sample analysis support for clinical trials involving sulfonamide-based therapeutics.
• Forensic and Anti-Doping Analysis: Supports confirmatory testing in forensic toxicology and sports anti-doping programs for sulfonamide detection.
• Environmental Fate Studies: Aids in tracking the environmental persistence and breakdown of sulfonamide antibiotics using isotope dilution techniques.

Basic Information

Product Name	n-Acetyl Sulfadiazine-13C6
CAS No.	1217089-17-2
Molecular Formula	C13C6H12N4O3S
Molecular Weight	~284.26 g/mol (for 13C6 labeled form)
Synonyms	N-[(4-Aminophenyl)sulfonyl]-13C6-acetamide; 4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide-13C6 N-acetate; Sulfadiazine-13C6 N-Acetyl; Acetylated Sulfadiazine-13C6; 13C6-Labeled N-Acetylsulfadiazine; Stable Isotope Labeled Sulfadiazine Metabolite; IS for Sulfadiazine LC-MS; [13C6]-N-Acetylsulfadiazine
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl Sulfadiazine-13C6 is manufactured and analyzed under strict quality systems. We guarantee high chemical purity and isotopic enrichment, typically ≥98% chemical purity and ≥99% atom % 13C, verified by advanced analytical techniques including NMR and HPLC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % 13C)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.