Description

Rac 2-Hydroxy Ibuprofen-D6 is a deuterated isotopologue of a key metabolite of ibuprofen, a widely used non-steroidal anti-inflammatory drug (NSAID). This compound is of significant value as an internal standard in quantitative bioanalytical methods, particularly liquid chromatography-mass spectrometry (LC-MS/MS), ensuring precise and accurate pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic manufacturers focused on drug metabolism and bioequivalence testing.

Application

• Primary use as a stable isotope-labeled internal standard for the quantification of 2-hydroxyibuprofen in biological matrices (plasma, serum, urine).
• Critical component in LC-MS/MS method development and validation for bioanalytical studies, enhancing data reliability.
• Supporting pharmacokinetic (PK) and pharmacodynamic (PD) research for ibuprofen and related prodrug formulations.
• Utilized in drug metabolism and excretion studies to understand metabolic pathways and clearance rates.
• Application in forensic and clinical toxicology for the accurate determination of ibuprofen metabolite levels.
• Used in academic and industrial research investigating the chiral metabolism of NSAIDs.

Basic Information

Product Name	Rac 2-Hydroxy Ibuprofen-D6
CAS No.	1217055-71-4
Molecular Formula	C13H12D6O3
Molecular Weight	228.31 g/mol (approx.)
Synonyms	2-Hydroxyibuprofen-d6; (±)-2-(4-Isobutylphenyl)propionic-3,3,4,4,5,5-d6 acid; 2-(4-(2-Methylpropyl)phenyl)propanoic-3,3,4,4,5,5-d6 acid; Ibuprofen Hydroxy Metabolite-d6; Ibuprofen-d6 Metabolite; 2-Hydroxyibuprofen (phenyl-d6); DL-2-Hydroxyibuprofen-D6
EINECS	Contact for details

Quality Control

Our Rac 2-Hydroxy Ibuprofen-D6 is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment (by MS), and chemical purity. We support compliance with GMP and ISO 9001 standards for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.