Description

Rac Indapamide-D3 is a deuterium-labeled analog of the thiazide-like diuretic indapamide, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses, particularly in pharmacokinetic and bioequivalence studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in drug metabolism and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of indapamide in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical Research & Development: Supports method development and validation for drug metabolism and pharmacokinetics (DMPK) studies.
• Bioanalytical Assays: Enhances data integrity in bioequivalence and clinical trial sample analysis.
• Forensic and Clinical Toxicology: Used in confirmatory testing for indapamide detection and quantification.
• Metabolite Identification: Aids in the structural elucidation of indapamide metabolites using isotopic patterns.
• Quality Control in Manufacturing: Serves as a reference standard for impurity profiling and assay validation of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Rac Indapamide-D3
CAS No.	1217052-38-4
Molecular Formula	C16H13D3ClN2O3S
Molecular Weight	366.85 g/mol (deuterated form)
Synonyms	Indapamide-d3; 4-Chloro-N-(2-methyl-1H-indol-1-yl)-3-sulfamoylbenzamide-d3; 1-(4-Chloro-3-sulfamoylbenzamido)-2-methylindole-d3; (±)-Indapamide-d3; Rac-Indapamide-d3; 3-(Aminosulfonyl)-4-chloro-N-(2-methyl-1-indolinyl)-benzamide-d3; SR 72022-d3
EINECS	Contact for details

Quality Control

Every batch of Rac Indapamide-D3 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and isotopic enrichment. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from NMR, HPLC, and mass spectrometry. Our quality protocols are designed to meet the stringent requirements of pharmaceutical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.