Description

2-Amino-3,4,8-Trimethyl-3H-Imidazo[4,5-F]Quinoxaline-D3 is a deuterium-labeled analog of a heterocyclic aromatic amine, specifically designed for use as an internal standard in advanced analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in mass spectrometry. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories focused on food safety, toxicology, and metabolic studies.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for the precise quantification of its non-deuterated counterpart and related compounds in LC-MS/MS and GC-MS workflows.
• Food Safety & Contaminant Analysis: Used in the detection and measurement of mutagenic heterocyclic aromatic amines (HAAs) formed in cooked protein-rich foods.
• Toxicology and Metabolite Studies: Enables accurate tracking of absorption, distribution, metabolism, and excretion (ADME) profiles in pharmacokinetic research.
• Method Development & Validation: Serves as a key reference material for developing and validating robust analytical methods in compliance with regulatory guidelines.
• Biomarker Research: Facilitates studies on DNA adduct formation and exposure biomarkers related to dietary or environmental factors.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of potential genotoxic impurities in active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Amino-3,4,8-Trimethyl-3H-Imidazo[4,5-F]Quinoxaline-D3
CAS No.	1216997-87-3
Molecular Formula	C12H9D3N5
Molecular Weight	215.25 g/mol (approx.)
Synonyms	2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline-d3; 4,8-Dimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine-3-methyl-d3; 4,8-DiMeIQx-d3 (common abbreviation); Deuterated 4,8-DiMeIQx; [2H3]-4,8-DiMeIQx; 2-Amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline (deuterated); Internal Standard for 4,8-DiMeIQx
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-3,4,8-Trimethyl-3H-Imidazo[4,5-F]Quinoxaline-D3 is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Comprehensive testing includes identity confirmation, assay by HPLC, and determination of deuterium incorporation. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.