Description

Didesethyl Chloroquine Hydroxyacetamide-D4 is a deuterated analog of a key chloroquine metabolite, serving as a critical stable isotope-labeled internal standard for precise analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, eliminating variability in sample preparation and analysis. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and diagnostic developers engaged in advanced pharmacokinetic studies, bioanalytical method development, and therapeutic drug monitoring for antimalarial and related therapies.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterium-labeled internal standard for the accurate quantification of chloroquine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic & Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Therapeutic Drug Monitoring (TDM): Critical for developing robust assays to monitor drug levels in patients, ensuring therapeutic efficacy and minimizing toxicity risks.
• Metabolite Identification & Profiling: Aids in the structural elucidation and quantification of drug metabolites, facilitating a deeper understanding of metabolic pathways.
• Biomarker Research: Used in method development for the detection and quantification of biomarkers related to drug response or disease states.
• Regulatory Compliance & Method Validation: Supports the development and validation of GLP/GCP-compliant bioanalytical methods required for regulatory submissions to agencies like the FDA and EMA.

Basic Information

Product Name	Didesethyl Chloroquine Hydroxyacetamide-D4
CAS No.	1216956-86-3
Molecular Formula	C₁₈H₂₂D₄ClN₃O₂
Molecular Weight	Contact for details
Synonyms	N-{4-[(7-Chloro-4-quinolinyl)amino]pentyl}-N-ethyl-2-hydroxyacetamide-1,1,2,2-d4; 1,1,2,2-Dideutero-N-(4-((7-chloroquinolin-4-yl)amino)pentyl)-N-ethyl-2-(hydroxydideuterio)acetamide; Didesethyl Hydroxychloroquine-d4 Metabolite; Bisnorchloroquine Hydroxyacetamide-d4; Deuterated Chloroquine Metabolite Standard; D4-Labeled Didesethyl Chloroquine Carboxylate; Stable Isotope-Labeled Internal Standard (SIL-IS) for Chloroquine; Chloroquine-d4 Metabolite IS
EINECS	Contact for details

Quality Control

Every batch of Didesethyl Chloroquine Hydroxyacetamide-D4 is manufactured and controlled under a strict quality management system. We guarantee high chemical and isotopic purity, with comprehensive testing performed using advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥95% by HPLC), isotopic enrichment (typically ≥98 atom % D), and absence of critical impurities. Our standards align with the requirements for research and diagnostic use under current good manufacturing practices (cGMP) where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.