Description

Bromperidol-D4 CAS NO 1216919-75-3 is a deuterated analog of the antipsychotic agent Bromperidol, where four hydrogen atoms are replaced with deuterium, serving as a critical internal standard for precise analytical quantification. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in sensitive mass spectrometry-based methods, particularly in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of Bromperidol in biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) by correcting for instrument variability and matrix effects.
• Bioanalytical Method Development and Validation: A key component in establishing and validating robust, regulatory-compliant analytical methods for clinical and preclinical trials.
• Forensic and Toxicology Analysis: Supports the precise identification and quantification of Bromperidol in forensic samples for legal and diagnostic purposes.
• Pharmaceutical Quality Control: Employed in impurity profiling and assay development for drug substance and finished product analysis.
• Stable Isotope Dilution Mass Spectrometry (SID-MS): Acts as the ideal spike-in standard for this highly accurate quantitative technique.

Basic Information

Product Name	Bromperidol-D4
CAS No.	1216919-75-3
Molecular Formula	C21H19D4BrFNO2
Molecular Weight	424.33 g/mol (approximate)
Synonyms	4-[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone-d4; 1-(4-Fluorophenyl)-4-[4-(4-bromophenyl)-4-hydroxy-1-piperidinyl]-1-butanone-d4; Bromperidol-d4; Bromperidol D4; Bromperidol (phenyl-d4); Deuterated Bromperidol; Bromperidol Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Bromperidol-D4 is manufactured and tested under strict quality management systems to ensure the highest isotopic and chemical purity required for analytical applications. We provide comprehensive Certificates of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and impurity profiles by techniques such as HPLC, NMR, and MS. Our quality commitment aligns with the standards expected for pharmaceutical reference materials and supports GLP/GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.