Description

n-Desethylamodiaquine-D5 Dihydrochloride is a high-purity, isotopically labeled internal standard critical for accurate quantitative analysis in modern bioanalytical workflows. This deuterated compound is essential for ensuring precision and reliability in mass spectrometry-based assays, particularly for pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in drug development and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the precise quantification of amodiaquine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Drug Metabolism Research: Used to study the metabolic pathways and biotransformation of amodiaquine, aiding in the understanding of efficacy and toxicity.
• Bioanalytical Method Development & Validation: A key component in developing robust, regulatory-compliant (FDA, EMA) analytical methods for bioequivalence and therapeutic drug monitoring.
• Forensic and Clinical Toxicology: Supports accurate detection and quantification of amodiaquine in cases of overdose or adverse drug reaction investigations.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and stability-indicating assays for drug substance and product quality assurance.

Basic Information

Product Name	n-Desethylamodiaquine-D5 Dihydrochloride
CAS No.	1216894-33-5
Molecular Formula	C20H17D5Cl2N3O
Molecular Weight	394.33 g/mol (for monoisotopic mass)
Synonyms	4-[(7-Chloro-4-quinolinyl)amino]-2-[(di-deuteromethyl)(deuterio)amino]-5-[(2-deuterioethyl)(deuterio)amino]phenol Dihydrochloride; Desethylamodiaquine-d5 Dihydrochloride; 2-[(Methyl-d3)(2H)amino]-α-[(2H2)ethylamino]-4-[(7-chloro-4-quinolyl)amino]-o-cresol Dihydrochloride; 4-[(7-Chloro-4-quinolyl)amino]-α-[(ethyl-d5)amino]-o-cresol Dihydrochloride; N-Desethyl Amodiaquine-d5 2HCl; Amodiaquine Desethyl Metabolite-d5 Dihydrochloride
EINECS	Contact for details

Quality Control

Our n-Desethylamodiaquine-D5 Dihydrochloride is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay purity, isotopic purity (D-enrichment), and impurity profile by HPLC. We adhere to relevant industry standards for reference materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.