Description

Bupropion Morpholinol-D6 is a deuterated isotopologue of a key metabolite of the antidepressant and smoking cessation aid bupropion. This labeled compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance testing for bupropion-based therapeutics.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity, stable isotope-labeled internal standard for the precise quantification of bupropion and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and non-clinical studies.
• Metabolite Profiling & Identification: Aids in the structural elucidation and quantification of bupropion metabolites during drug metabolism and pharmacodynamics (DMPK) research.
• Bioequivalence & Generic Drug Development: Critical for analytical methods supporting the development and regulatory filing of generic bupropion formulations.
• Forensic & Clinical Toxicology: Used in method development for the accurate detection and quantification of bupropion in forensic and therapeutic drug monitoring (TDM) applications.
• Quality Control in Reference Material Production: Serves as a critical component in the preparation and validation of certified reference materials (CRMs) for analytical laboratories.

Basic Information

Product Name	Bupropion Morpholinol-D6
CAS No.	1216893-18-3
Molecular Formula	C13H12D6ClNO
Molecular Weight	245.79 g/mol
Synonyms	(±)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-ol-d6; 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanol-d6; Hydroxybupropion-d6; BW 306U-d6; (1RS)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]propan-1-ol-d6; Radafaxine metabolite-d6; Bupropion metabolite-d6
EINECS	Contact for details

Quality Control

Our Bupropion Morpholinol-D6 is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced spectroscopic and chromatographic analyses, including NMR, HPLC, and LC-MS. We adhere to ISO 9001 quality management principles, and our processes are designed to support compliance with GMP and ICH guidelines for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Content)	≥98.0 atom % D
Chemical Purity (by HPLC)	≥98.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.