Description

Irbesartan-D4 is a stable isotope-labeled analog of the antihypertensive drug Irbesartan, specifically deuterated at four positions. This high-purity reference standard is essential for ensuring the accuracy and reliability of quantitative analytical methods in pharmaceutical research and quality control. It is primarily used by scientists and quality assurance professionals in pharmaceutical development, clinical research, and forensic toxicology for applications requiring precise internal standardization.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of Irbesartan in biological matrices (plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Pharmaceutical Quality Control (QC): Used in the development and validation of robust analytical methods to assay Irbesartan in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Metabolite Identification and Profiling: Aids in the identification and quantification of Irbesartan metabolites in complex biological samples.
• Forensic and Doping Control Analysis: Provides a reliable reference for the confirmatory analysis of Irbesartan in forensic toxicology and anti-doping programs.
• Method Development and Validation: Fundamental for developing new, sensitive, and specific analytical procedures in compliance with ICH and FDA guidelines.

Basic Information

Product Name	Irbesartan-D4
CAS No.	1216883-23-6
Molecular Formula	C25H24D4N6O
Molecular Weight	432.56 g/mol
Synonyms	2-Butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one-d4; Deuterated Irbesartan; Irbesartan (tetradeuterated); Irbesartan-d4; 2-Butyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one-d4; BMS-186295-d4; SR 47436-d4
EINECS	Contact for details

Quality Control

Our Irbesartan-D4 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Each batch is supplied with a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and purity by HPLC. We adhere to strict quality management protocols suitable for research and development use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.