Description

Dehydro Nicardipine Hcl is a high-purity pharmaceutical intermediate and reference standard. This compound is critical for research and development in cardiovascular pharmacology, serving as a key derivative in the study of calcium channel blockers. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in drug discovery and analytical method development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis and research of advanced nicardipine analogs and related cardiovascular active pharmaceutical ingredients (APIs).
• Reference Standard: Used for analytical purposes, including method validation, quality control (QC), and impurity profiling in pharmaceutical manufacturing.
• Biochemical Research: Employed in preclinical studies to investigate the structure-activity relationships (SAR) of dihydropyridine calcium antagonists.
• Metabolite Studies: Serves as a reference compound for the identification and quantification of nicardipine metabolites in pharmacokinetic and bioanalytical research.
• Process Development: Used in the development and optimization of synthetic routes for next-generation calcium channel blockers.

Basic Information

Product Name	Dehydro Nicardipine Hcl
CAS No.	1216817-27-4
Molecular Formula	C26H28N3O6 • HCl
Molecular Weight	516.0 g/mol (approx.)
Synonyms	Dehydronicardipine Hydrochloride; Nicardipine Impurity; Nicardipine Related Compound; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]ethyl ester 5-methyl ester hydrochloride; Nicardipine Dehydro Derivative HCl; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-[2-(benzylmethylamino)ethyl] 5-methyl ester, hydrochloride; Dehydro Nicardipine Hydrochloride
EINECS	Contact for details

Quality Control

Our Dehydro Nicardipine Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all test results against established specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.