Description

Rac Naproxen-13C,D3 is a stable isotope-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) Naproxen, specifically designed for use as an internal standard in quantitative mass spectrometry. This compound is critical for ensuring the accuracy and reliability of analytical methods by correcting for variations in sample preparation and instrument response. It is an essential tool for pharmaceutical research and development, clinical laboratories, and regulatory agencies engaged in drug metabolism studies, pharmacokinetic analysis, and bioequivalence testing.

Application

• Quantitative Bioanalysis: Serves as an internal standard in LC-MS/MS and GC-MS methods for the precise quantification of Naproxen and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Impurity Profiling: Used in method development and validation to assess and control related substances in active pharmaceutical ingredient (API) batches.
• Forensic & Doping Control: Supports confirmatory testing in forensic toxicology and anti-doping programs where precise NSAID quantification is required.
• Regulatory Compliance & Method Validation: Essential for developing and validating analytical methods that meet stringent FDA, EMA, and ICH guidelines for bioanalytical assays.

Basic Information

Product Name	Rac Naproxen-13C,D3
CAS No.	1216704-11-8
Molecular Formula	C1413CH11D3O3
Molecular Weight	~234.28 g/mol
Synonyms	(±)-2-(6-Methoxy-2-naphthyl)propionic-13C,3,3,3-d3 acid; Naproxen-(phenyl-13C, methyl-d3); DL-Naproxen-13C,D3; 2-(6-Methoxynaphthalen-2-yl)propanoic-13C,3,3,3-d3 acid; Rac-NAP-13C,D3; Isotopically Labeled Naproxen; Naproxen Internal Standard; NSAID Isotopologue
EINECS	Contact for details

Quality Control

Our Rac Naproxen-13C,D3 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C and D), chemical purity by HPLC, and confirmation of structure by NMR and MS. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable performance and traceability in your analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the container to reach room temperature in a desiccator before opening to minimize moisture absorption. For optimal stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99%
Isotopic Enrichment (Atom % D)	≥ 98%
Chemical Purity (by 1H NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.