Description

4-Amino-5-Ethylsulfonyl-2-Methoxy-n-[[1-(1,1,2,2,2-Pentadeuterioethyl)Pyrrolidin-2-Yl]Methyl]Benzamide is a deuterated organic compound of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled internal standard or a key synthetic intermediate for mass spectrometry-based analytical methods. This high-purity specialty chemical is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise quantification and metabolic studies of novel drug candidates.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled analog for the accurate quantification of its non-deuterated counterpart in bioanalytical assays (plasma, serum, tissue).
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Synthetic Intermediate: Serves as a building block in the synthesis of more complex deuterated active pharmaceutical ingredients (APIs) or probe molecules.
• Biomarker Research: Facilitates the development of highly specific and sensitive diagnostic assays for disease biomarkers.
• Pharmaceutical Reference Standard: Provides a certified reference material for method validation, quality control, and regulatory submissions.
• Isotope Dilution Analysis: Critical for achieving high accuracy and precision in quantitative analytical chemistry within regulated laboratories.

Basic Information

Product Name	4-Amino-5-Ethylsulfonyl-2-Methoxy-n-[[1-(1,1,2,2,2-Pentadeuterioethyl)Pyrrolidin-2-Yl]Methyl]Benzamide
CAS No.	1216626-17-3
Molecular Formula	C18H24D5N3O4S
Molecular Weight	~394.55 g/mol
Synonyms	4-Amino-5-ethylsulfonyl-2-methoxy-N-{[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl}benzamide; Deuterated Benzamide Derivative; 2-Methoxy-4-amino-5-ethylsulfonyl-N-[(1-(pentadeuterioethyl)-2-pyrrolidinyl)methyl]benzamide; [D5]-Labeled Analog; Stable Isotope-Labeled Internal Standard; CAS 1216626-17-3; 4-Amino-5-(ethylsulfonyl)-2-methoxy-N-({1-[(1,1,2,2,2-2H5)ethyl]-2-pyrrolidinyl}methyl)benzamide
EINECS	Contact for details

Quality Control

Our high-purity deuterated compounds are manufactured under strict quality systems to ensure batch-to-batch consistency and data integrity for critical research. Each lot undergoes comprehensive analysis including HPLC for chemical purity, NMR and MS for structural confirmation, and isotopic enrichment verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all specifications. Production adheres to cGMP principles where applicable, supporting use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.