Description

Cyamemazine-D6 is a deuterium-labeled internal standard of the antipsychotic agent cyamemazine, essential for ensuring accuracy and precision in quantitative bioanalytical methods. This stable isotope-labeled compound is critical for researchers and laboratories requiring the highest level of data integrity in pharmacokinetic and metabolic studies. It is primarily used by pharmaceutical R&D teams, contract research organizations (CROs), and forensic toxicology laboratories engaged in advanced LC-MS/MS analysis.

Application

• Quantitative Bioanalysis: Serves as an internal standard for the precise quantification of cyamemazine in biological matrices (plasma, serum, urine) using LC-MS/MS.
• Pharmacokinetic Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Forensic Toxicology: Used in confirmatory testing and method development for the detection of cyamemazine in forensic applications.
• Method Development & Validation: A critical tool for developing, optimizing, and validating robust analytical methods in compliance with GLP and ICH guidelines.
• Drug Metabolism Research: Facilitates the identification and quantification of drug metabolites in complex biological systems.
• Quality Control in Manufacturing: Supports impurity profiling and stability testing of pharmaceutical formulations containing cyamemazine.

Basic Information

Product Name	Cyamemazine-D6
CAS No.	1216608-24-0
Molecular Formula	C19H15D6N3S
Molecular Weight	329.47 g/mol (approximate)
Synonyms	Deuterated Cyamemazine; Cyamemazine (hexadeuterated); 10-[3-(Dimethylamino)propyl]-2-(methyl-d3)-10H-phenothiazine-2-carbonitrile-d3; (Perdeuteromethyl)-cyanemazine; Cyamemazine Internal Standard; Cyamemazine-d6; CRM 7101-d6 (potential reference material code)
EINECS	Contact for details

Quality Control

Our Cyamemazine-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity by HPLC, and residual solvent content. We adhere to relevant industry standards for reference materials to support your compliance with GLP and ICH Q2(R1) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 99.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.