Description

D,L-Venlafaxine-D10 Hydrochloride is a deuterium-labeled internal standard of the antidepressant venlafaxine, specifically designed for analytical and research applications. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic studies and therapeutic drug monitoring. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise and stable isotopic labels for mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of venlafaxine and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust analytical methods to optimize patient dosage and ensure therapeutic efficacy.
• Metabolite Profiling and Identification: Aids in the structural elucidation and quantification of venlafaxine metabolites in complex samples.
• Method Development and Validation: Serves as a key reference material for establishing specificity, accuracy, and precision in new analytical protocols.
• Quality Control in Pharmaceutical Manufacturing: Used in impurity profiling and stability-indicating assays for venlafaxine hydrochloride drug substances and products.

Basic Information

Product Name	D,L-Venlafaxine-D10 Hydrochloride
CAS No.	1216539-56-8
Molecular Formula	C17H17D10ClNO2 • HCl
Molecular Weight	~ 337.90 g/mol (for monoisotopic)
Synonyms	Venlafaxine-d10 Hydrochloride; (±)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol-d10 Hydrochloride; DL-Venlafaxine-d10 HCl; Venlafaxine (D10) Hydrochloride; 1-[2-(Dimethyl-d6-amino)-1-(4-methoxyphenyl-d4)ethyl]cyclohexanol Hydrochloride; Deuterated Venlafaxine HCl; Venlafaxine Internal Standard-d10
EINECS	Contact for details

Quality Control

Our D,L-Venlafaxine-D10 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.