Description

Lornoxicam-D4 CAS NO 1216527-48-8 is a high-purity, deuterium-labeled internal standard essential for precise quantitative analysis in pharmaceutical research and development. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based assays, particularly for pharmacokinetic and bioequivalence studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies focused on the development and quality control of non-steroidal anti-inflammatory drugs (NSAIDs).

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of Lornoxicam in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Enables precise pharmacokinetic (PK) and pharmacodynamic (PD) studies during drug development and clinical trials.
• Bioanalytical Method Development: Used to validate and optimize analytical methods, ensuring high specificity, sensitivity, and reproducibility.
• Metabolite Profiling: Aids in the identification and quantification of drug metabolites in metabolism and disposition studies.
• Quality Control & Assurance: Supports impurity profiling and assay validation for active pharmaceutical ingredient (API) manufacturers.
• Regulatory Submissions: Provides the data integrity required for compliant submissions to agencies like the FDA and EMA.

Basic Information

Product Name	Lornoxicam-D4
CAS No.	1216527-48-8
Molecular Formula	C13H6D4ClN3O4S2
Molecular Weight	372.30 g/mol (approximate)
Synonyms	6-Chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide-d4; Lornoxicam-d4; Deuterated Lornoxicam; Lornoxicam (D4); Lornoxicam Internal Standard; Chlortenoxicam-d4; Ro 13-9297-d4; (2Z)-6-Chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-yl-1λ6,2-dihydrothieno[2,3-e][1,2]thiazine-3-carboxamide-d4
EINECS	Contact for details

Quality Control

Our Lornoxicam-D4 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and impurity profiles. We adhere to relevant industry standards for reference materials, and our quality commitment supports compliance in GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.