Description

Decarboxy Tianeptine-D12 Nitrile is a high-purity, deuterium-labeled internal standard critical for advanced analytical applications. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analysis, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic science facilities requiring precise measurement of its parent compound and related metabolites.

Application

• Internal Standard for LC-MS/MS: Serves as a deuterated internal standard for the precise quantification of Tianeptine and its metabolites in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical R&D & Metabolism Studies: Enables accurate pharmacokinetic profiling, bioavailability studies, and investigation of metabolic pathways in drug development.
• Forensic Toxicology & Clinical Research: Supports method development and validation for the detection and quantification of substances in forensic analysis and clinical trial sample testing.
• Reference Material for Method Validation: Used as a certified reference material (CRM) to validate analytical methods, ensuring compliance with regulatory guidelines like FDA 21 CFR Part 11 and ICH Q2(R1).
• Quality Control in API Manufacturing: Acts as a critical tool for in-process control and final product release testing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Decarboxy Tianeptine-D12 Nitrile
CAS No.	1216525-46-0
Molecular Formula	C₂₁H₁₇D₁₂N₃O₃S
Molecular Weight	~431.6 g/mol
Synonyms	7-[(3-Chloro-6-methyl-5,5-dideutero-6,6,7,7,8,8,9,9,10,10,11,11-dodecadeutero-5H-dibenzo[c,f][1,2]thiazepin-11-yl)amino]-7-oxoheptanenitrile; Tianeptine D12 Nitrile Metabolite; Deuterated Tianeptine Acid Nitrile; Tianeptine-d12 Carboxylic Acid Nitrile; Tianeptine Metabolite D12 Nitrile; 1216525-46-0; ST 2001-d12 Nitrile Analog
EINECS	Contact for details

Quality Control

Every batch of Decarboxy Tianeptine-D12 Nitrile is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, confirmed by advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data for purity, isotopic enrichment, and solvent residues to support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.