Description

Metoclopramide-D3 is a deuterium-labeled analog of the pharmaceutical compound metoclopramide, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for Bioanalysis: Critical for the precise quantification of metoclopramide in biological matrices (plasma, serum, urine) using LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical Quality Control: Used in the development and validation of analytical methods for drug substance and drug product testing.
• Forensic and Clinical Toxicology: Supports accurate measurement of metoclopramide levels in cases of overdose or therapeutic drug monitoring.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the ideal spike for achieving high-precision measurements in reference methodology.

Basic Information

Product Name	Metoclopramide-D3
CAS No.	1216522-89-2
Molecular Formula	C14H19D3ClN3O2
Molecular Weight	300.81 g/mol (deuterated form)
Synonyms	4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide-D3; 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide-D3; Metoclopramide (methyl-d3); Deuterated Metoclopramide; Metoclopramide-d3 Internal Standard; Reglan-d3; Maxolon-d3; Primperan-d3; CLR 140-d3
EINECS	Contact for details

Quality Control

Our Metoclopramide-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, isotopic enrichment (typically ≥98 atom % D), and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 95.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.