Description

Azasetron-D3, Hydrochloride is a deuterium-labeled analog of the potent and selective 5-HT3 receptor antagonist, Azasetron. This stable isotope-labeled compound is an essential reference standard and internal standard for quantitative bioanalytical studies, ensuring accurate and reliable pharmacokinetic and metabolic data. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in mass spectrometry.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise quantification of Azasetron and its metabolites in biological matrices like plasma, serum, and urine.
• Deuterated Reference Material: Used in method development and validation for bioanalytical assays to ensure specificity and accuracy.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile.
• Pharmaceutical Quality Control: Serves as a certified reference standard for impurity profiling and assay development of Azasetron drug substances and products.
• Clinical Research: Supports analytical work in clinical trials investigating Azasetron's efficacy and safety profile.

Basic Information

Product Name	Azasetron-D3, Hydrochloride
CAS No.	1216505-58-6
Molecular Formula	C17H19D3N4O2•HCl
Molecular Weight	356.86 g/mol (approx.)
Synonyms	Azasetron-d3 hydrochloride; (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-(methyl-d3)-4H-chromene-8-carboxamide hydrochloride; Y-25130-d3 hydrochloride; Deuterated Azasetron HCl; Azasetron (methyl-d3) hydrochloride
EINECS	Contact for details

Quality Control

Our Azasetron-D3, Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including NMR (1H, 13C) and Mass Spectrometry for structural confirmation and isotopic purity assessment. We guarantee high chemical and isotopic purity suitable for sensitive analytical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and chromatographic data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (LC-MS)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.