Description

2-[[3-Methyl-4-[3-(Trideuteriomethoxy)Propoxy]Pyridin-2-Yl]Methylsulfinyl]Benzimidazol-1-Ide is a deuterated derivative of a proton pump inhibitor (PPI) class compound, offering enhanced metabolic stability for advanced pharmaceutical research and development. This compound is critical for use as an internal standard in mass spectrometry and as a stable isotope-labeled tracer in pharmacokinetic and drug metabolism studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in the development of novel gastrointestinal therapeutics and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantitative analysis of its non-deuterated counterpart in biological matrices.
• Stable Isotope-Labeled Tracer: Used in Absorption, Distribution, Metabolism, and Excretion (ADME) studies to track drug pathways and metabolites with high specificity.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during drug substance development.
• Metabolite Identification: Facilitates the structural elucidation of drug metabolites in complex biological samples through advanced spectroscopic techniques.
• Bioanalytical Method Development: Essential for creating and validating robust, sensitive, and accurate analytical methods compliant with FDA and ICH guidelines.
• Clinical Research: Supports clinical trial sample analysis to ensure reliable pharmacokinetic data for regulatory submissions.

Basic Information

Product Name	2-[[3-Methyl-4-[3-(Trideuteriomethoxy)Propoxy]Pyridin-2-Yl]Methylsulfinyl]Benzimidazol-1-Ide
CAS No.	1216494-11-9
Molecular Formula	C18H20D3N3O3S
Molecular Weight	362.47 g/mol
Synonyms	Deuterated Omeprazole-d3 (Methoxy-d3); 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-d3; Omeprazole-d3 (CD3O-); 2-(((4-Methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-5-(trideuteriomethoxy)-1H-benzo[d]imidazole; (RS)-Omeprazole-d3; 5-(Trideuteriomethoxy)-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems to ensure the highest isotopic and chemical purity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, isotopic enrichment (typically >98 atom % D), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided and traceable to relevant standards for pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.