Description

[U-Ring-13C6]-Ibuprofen is a stable isotope-labeled analog of the common non-steroidal anti-inflammatory drug (NSAID), ibuprofen, where six carbon atoms on the phenyl ring are replaced with the carbon-13 isotope. This compound is essential as an internal standard in quantitative mass spectrometry, enabling highly accurate and precise measurements by correcting for variations in sample preparation and instrument response. It is a critical tool for researchers and quality control laboratories in pharmaceutical development, clinical research, forensic toxicology, and environmental analysis who require definitive data for method validation and regulatory compliance.

Application

• Quantitative Bioanalysis: Serves as an internal standard in LC-MS/MS and GC-MS methods for the precise quantification of ibuprofen and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Metabolite Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in both preclinical and clinical research settings.
• Pharmaceutical Quality Control: Used in assay development and validation to ensure the accuracy of potency and impurity profiling for ibuprofen-containing drug products.
• Forensic and Clinical Toxicology: Facilitates reliable identification and quantification of ibuprofen in cases of overdose or for therapeutic drug monitoring.
• Environmental Monitoring: Applied in methods to detect and quantify pharmaceutical residues, including ibuprofen, in water and soil samples.
• Stable Isotope Dilution Assays (SIDA): Provides the foundation for this gold-standard quantitative technique across various analytical chemistry applications.

Basic Information

Product Name	[U-Ring-13C6]-Ibuprofen
CAS No.	1216459-54-9
Molecular Formula	C13H18O2 * (13C6)
Molecular Weight	~210.3 (exact mass depends on isotopic enrichment)
Synonyms	Ibuprofen-13C6 (phenyl-13C6); 2-(4-Isobutylphenyl)propionic acid-13C6 (phenyl ring); (RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid-13C6; 13C6-Ibuprofen; Isotopically Labeled Ibuprofen; Ibuprofen Internal Standard; Ibuprofen-d0 (13C6); NSAID Stable Isotope Standard
EINECS	Contact for details

Quality Control

Every batch of [U-Ring-13C6]-Ibuprofen is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail critical parameters including isotopic purity (atom % 13C), chemical purity (by HPLC), and the absence of unlabeled ibuprofen. Our quality protocols are designed to meet the rigorous demands of analytical reference standard applications, supporting compliance with GLP and ISO 17025 standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥98.0%
Isotopic Purity (13C)	≥99 atom % 13C (on labeled positions)
Chemical Purity (by HPLC)	≥95.0%
Unlabeled Ibuprofen	≤1.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.