Description

Zolpidem Phenyl-4-Carboxylic Acid Ethyl Ester-D6 is a deuterium-labeled analog of a key intermediate in the synthesis of Zolpidem, a widely prescribed sedative-hypnotic. This stable isotope-labeled compound is essential for the development and validation of highly sensitive and accurate analytical methods, particularly in pharmacokinetic and metabolic studies. It serves as a critical internal standard for researchers and quality control laboratories in the pharmaceutical industry, ensuring precise quantification and reliable data integrity.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of Zolpidem and related metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential internal standard in LC-MS/MS and GC-MS assays to study the absorption, distribution, metabolism, and excretion (ADME) profile of Zolpidem.
• Forensic and Clinical Toxicology: Used in method development for the accurate detection and measurement of Zolpidem in blood, urine, and plasma samples.
• Process Chemistry Research: Acts as a labeled tracer in synthetic pathway studies and for monitoring reaction mechanisms during the development of Zolpidem and its analogs.
• Quality Control & Assurance: Critical for ensuring batch-to-batch consistency and purity in the manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Zolpidem Phenyl-4-Carboxylic Acid Ethyl Ester-D6
CAS No.	1216455-48-9
Molecular Formula	C20H15D6N3O3
Molecular Weight	345.41 g/mol
Synonyms	Ethyl 6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carboxylate-D6; Zolpidem Impurity D6 (Ethyl Ester); Zolpidem Related Compound D6; Zolpidem Carboxylic Acid Ethyl Ester-D6; Deuterated Zolpidem Ethyl Ester; [D6]-Zolpidem Phenyl-4-Carboxylic Acid Ethyl Ester; 2-(4-Methylphenyl)-6-methylimidazo[1,2-a]pyridine-3-carboxylic Acid Ethyl-d6 Ester
EINECS	Contact for details

Quality Control

Every batch of Zolpidem Phenyl-4-Carboxylic Acid Ethyl Ester-D6 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a high-purity reference standard. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including isotopic purity (D-content), chemical purity (by HPLC), and identification (by NMR and MS). Our quality commitment ensures compliance with the rigorous standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by NMR)	≥ 97.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.