Description

Norverapamil-D6, Hydrochloride is a deuterium-labeled internal standard of the calcium channel blocker verapamil, essential for precise quantitative analysis in bioanalytical research. This high-purity, isotopically labeled compound is critical for ensuring accuracy and reliability in pharmacokinetic and metabolic studies using mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on cardiovascular drug development and analytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of verapamil and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise studies on the absorption, distribution, metabolism, and excretion (ADME) profile of verapamil in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to develop, optimize, and validate robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Clinical Trial Support: Provides reliable data for therapeutic drug monitoring (TDM) and bioequivalence studies during clinical trials involving verapamil formulations.
• Forensic and Anti-Doping Analysis: Supports accurate detection and quantification of verapamil in forensic toxicology and sports anti-doping control programs.

Basic Information

Product Name	Norverapamil-D6, Hydrochloride
CAS No.	1216413-74-9
Molecular Formula	C₂₇H₃₂D₆ClN₂O₄ • HCl
Molecular Weight	~ 525.1 g/mol
Synonyms	Verapamil D6 (Norverapamil) Hydrochloride; (±)-Norverapamil-d6 Hydrochloride; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile-d6 Hydrochloride; 2-Isopropyl-2-(3,4-dimethoxyphenyl)-5-[(3,4-dimethoxyphenethyl)methylamino]valeronitrile-d6 Hydrochloride; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzenepropanenitrile-d6 Hydrochloride; Norverapamil D6 HCl; Norverapamil-d6 HCl
EINECS	Contact for details

Quality Control

Every batch of Norverapamil-D6, Hydrochloride is manufactured and tested under strict quality management systems to ensure the highest standards of purity and isotopic enrichment required for sensitive analytical applications. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.