Description

Alfuzosin-D3 Hydrochloride is a deuterated isotopologue of the selective α-1 adrenergic receptor antagonist, Alfuzosin Hydrochloride. This high-purity stable-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the accuracy and reliability of pharmacokinetic and metabolism studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and quality control of generic and branded formulations containing Alfuzosin.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise quantification of Alfuzosin in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioequivalence Studies: Used in clinical trials to study drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolites in in vitro and in vivo studies.
• Method Development and Validation: Serves as a reference standard for developing robust and compliant analytical methods according to ICH, FDA, and EMA guidelines.
• Quality Control in Pharmaceutical Manufacturing: Ensures batch-to-batch consistency and purity of the active pharmaceutical ingredient (API).

Basic Information

Product Name	Alfuzosin-D3 Hydrochloride
CAS No.	1216383-97-9
Molecular Formula	C19H24D3N5O4 • HCl
Molecular Weight	425.94 g/mol (for monohydrochloride)
Synonyms	Alfuzosin-d3 HCl; N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide-d3 Hydrochloride; (RS)-N-[3-[(4-Amino-6,7-dimethoxyquinazolin-2-yl)methylamino]propyl]tetrahydrofuran-2-carboxamide-d3 Hydrochloride; Alfuzosin (methyl-d3) Hydrochloride
EINECS	Contact for details

Quality Control

Our Alfuzosin-D3 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity, NMR and MS for structural confirmation, and specific tests for isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.